The Minister of Health and Social Services (in French: Ministère de la Santé et des Services sociaux) is responsible for the administration of health and social services in the province of Quebec since June 1985. It was previously the responsibility of the Minister of Social Affairs.
The following people have served as Quebec's Minister of Health and Social Services:
| Name | Took Office | Left Office | Party | |
| Guy Chevrette | June 21, 1985 | December 12, 1985 | Parti Québécois | |
| Thérèse Lavoie-Roux | December 12, 1985 | October 11, 1989 | Liberal | |
| Marc-Yvan Côté | October 11, 1989 | January 11, 1994 | Liberal | |
| Lucienne Robillard | January 11, 1994 | September 26, 1994 | Liberal | |
| Jean Rochon | September 26, 1994 | December 15, 1998 | Parti Québécois | |
| Pauline Marois | December 15, 1998 | March 8, 2001 | Parti Québécois | |
| Rémy Trudel | March 8, 2001 | January 30, 2002 | Parti Québécois | |
| François Legault | January 30, 2002 | April 29, 2003 | Parti Québécois | |
| Philippe Couillard | April 29, 2003 | June 25, 2008 | Liberal | |
| Yves Bolduc | June 25, 2008 | Incumbent | Liberal |